M2 research projects - stem cells
Neural stem cells (NSC) are multipotent cells that are capable of differentiating into the main phenotypes of the nervous system - producing a diversity of neurons, astrocytes and oligodendrocytes. Given their ability to differentiate into various types of neuronal lineages, these cells can be applied to cure neurodegenerative diseases. In vitro NSCs can currently be derived from human embryonic stem cells (hESC). In order to successfully apply NSCs in regenerative medicine it is important to understand the underlying mechanisms of hESC differentiation towards neuronal lineages.
Some possible future uses for NSCs could be:
The main aim of the project is to understand what genes separate hESCs and NSCs originated from different experiments and microarray platforms. In addition, we investigate how much does the technology and human factor influence the derived cell lines.
Märt Roosaare and Mikk Puustusmaa
Department of bioinformatics, university of tartu
Some possible future uses for NSCs could be:
- Myelin restoration (using oligodendrocytes)
- Mixed pools of progenitors to cure complex populations of neural cells (spinal cord injuries)
- Laboratory experiments where neural cells are required
The main aim of the project is to understand what genes separate hESCs and NSCs originated from different experiments and microarray platforms. In addition, we investigate how much does the technology and human factor influence the derived cell lines.
Märt Roosaare and Mikk Puustusmaa
Department of bioinformatics, university of tartu